Sunitinib malate solubility in water

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August undefined, 2024

WebSunitinib Malate. Product ID S8253. Cas No. 341031-54-7. Purity ≥98%. Product Unit Size Cost Quantity Stock. ... Sutent. Melting Point: 194-200°C. Solubility: Soluble in DMSO at … WebThe solubility of sunitinib malate in aqueous media over the range pH 1.2 to pH 6.8 is in excess of 25 mg/mL. The log of the distribution coefficient (octanol/water) at pH 7 is 5.2. …

Sunitinib Malate - NCI - National Cancer Institute

Web1 Apr 2024 · The solubility of this medicine quickly diminishes at the pH values>6.8 (water solubility"1 mg mL −1) [6]. Once used orally, the Sunitinib is known to follow a slow … WebName: Sunitinib malate CAS#: 341031 -54 -7 Lot#: TZC50127 Chemical Formula: C 26 H 33 FN 4 O 7 Exact Mass:523.23 Molecular Weight: 532.56 Analysis item Specifications / … the song valencia

Sunitinib Malate ≥99%(HPLC) RTK inhibitor AdooQ®

WebEP2 362 873B1 3 5 10 15 20 25 30 35 40 45 50 55 [0011] The present invention satisfies this need by providing an improved process for repeatedly obtaining a desired specific, … WebWater temperature can have a significant effect on the solubility of compounds. Refer to the chart below to find reference values per gram of common compounds and salts (with … the song vampire

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An improved synthesis of sunitinib malate via a solvent-free ...

WebSolubility: Soluble in DMSO at 40 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM; buffers, … WebSolubility (25°C) DMSO 15 mg/mL Water <1 mg/mL Ethanol <1 mg/mL Storage Description Sunitinib Malate (Sutent, SU11248) is a potent RTK inhibitor targeting VEGFR2 (Flk-1) and … the song valerie originalWeb23 Feb 2024 · Sunitinib, Free Base is a free base form of Sunitinib malate salt (sc-220247) which is used for the study of imatinib-resistant gastrointestinal stromal tumor (GIST) … myrtle beach gospel brunch

"WebSunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of … " - Sunitinib malate solubility in water

Sunitinib malate solubility in water

What is the best solvent for dissolving sunitinib malate?

Web5 May 2015 · To search for an economical and convenient synthesis of sunitinib and its malate salt, optimization of a scalable synthetic route was explored by designing a … WebFor research use only. Sunitinib (SU11248) malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 …

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Web13 Mar 2015 · It also is a potent, ATP-competitive inhibitor of VEGFR, PDGFR-β and c-Kit (KIT). Sunitiba Malate inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. … WebSunitinib malate is a hydrophobic drug with very poorly water-soluble properties. I'm going to incorporate sunitinib into beta-cyclodextrin (inclusion complex CD/Drug) then, loaded this...

Web1 Jul 2024 · Sunitinib, Malate Salt, >99%, CAS#341031-54-7, More than 820 labs worldwide have purchased Sunitinib or its salt forms from LC Labs (either directly from us or from … WebSunitinib (malate) is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, sunitinib (malate) should first be dissolved in DMSO and then diluted …

WebSunitinib malate is a yellow to orange powder with a pKa of 8.95. The solubility of sunitinib malate in aqueous media over the range pH 1.2 to pH 6.8 is in excess of 25 mg/mL. The … WebSunitinib C22H27FN4O2 CID 5329102 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

WebProduct information "Sunitinib, Malate Salt (Sunitinib Maleate, Sutent, SU-11248, PHA-290940AD, PNU-290940AD, CAS 341031-" Soluble in DMSO at 40 mg/mL, very poorly …

WebSunitinib malate: Capsule: 12.5 mg/1: Oral: Northstar RxLLC: 2024-02-18: Not applicable: US: Sunitinib Malate: Capsule: 37.5 mg/1: Oral: Mylan Pharmaceuticals Inc. 2024-01-04: Not … the song vaya con diosWeb1 Jun 2024 · Solubility of sunitininb malate (SM) in various cosolvents/mixtures was determined. • The mole fraction solubilities of SM were found highest in neat Transcutol … the song vaultWebSunitinib malate (SM) is reported as a weakly soluble drug in water due to its poor dissolution rate and oral bioavailability. Hence, in the current study, various "self … the song vegas cleanWeb10 Nov 2024 · Sunitinib malate 341031-54-7 Not Listed STOT RE. 1 (H372) Repr 1B (H360D) Aquatic Acute 1 (H400) Acute Chronic 1 (H410) 15-40 Magnesium stearate 557-04-0 209 … myrtle beach governmentWeb1 Mar 2024 · The mole fraction solubilities of SM were obtained maximum in pure THP (1.87 × 10⁻²) followed by PEG-400, IPA, ethanol, PG, EG and water (1.05 × 10⁻⁵) at “T = 318.2 K”. … the song vehicle youtubeWeb9 Sep 2024 · The chemical structure of sunitinib malate is: Sunitinib malate is a yellow to orange powder with a pKa of 8.95. The solubility of sunitinib malate in aqueous media … myrtle beach government jobsWebCAS NO. 341031-54-7. Sunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor for the treatment of renal cell carcinoma (RCC) and imatinib … the song vehicle