http://pathology.ucla.edu/workfiles/Education/Residency%20Program/Gross%20Manual/AncillaryTestsFINAL111319.pdf WebJul 3, 2006 · The MECT1-MAML2 fusion transcript was detected by a reverse transcription-PCR assay, which can be applied to both histologic and cytologic specimens. The presence of the fusion transcript was correlated with relevant clinicopathologic and survival data of the mucoepidermoid carcinoma patients.
MECT1-MAML2 Fusion Transcript Defines a Favorable Subset of ...
http://www.cancerindex.org/geneweb/MAML2.htm WebMar 21, 2024 · MAML2 (Mastermind Like Transcriptional Coactivator 2) is a Protein Coding gene. Diseases associated with MAML2 include Hidradenoma and Salivary Gland Carcinoma . Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Regulation of activated PAK-2p34 by proteasome mediated … trend tributes
Role of CRTC1/MAML2 Translocation in the Prognosis and ... - PubMed
WebJun 1, 2024 · The dominant role of MAML2 might be due to higher expression of MAML2 than MAML1 in lung tissues, which has been shown (50, 51). We show that MAML1/2 not only promote nuclear localization of YAP/TAZ, they also enhance YAP/TAZ–TEAD-mediated transcriptional activity via forming a functional complex ( Fig. 4 ). WebApr 8, 2014 · Primary pulmonary mucoepidermoid carcinoma (PMEC) is an uncommon neoplasm with remarkable resemblance to mucoepidermoid carcinoma of the salivary glands. The latter has been shown to harbor t (11,19) resulting in MECT1-MAML2 fusion, which may be of diagnostic and prognostic values. WebFeb 26, 2024 · We identified 11 patients with thymomas harboring a gene fusion of KMT2A and mastermind-like transcriptional coactivator 2 (MAML2).Fusion breakpoints were identified between exon 8, 9, 10, or 11 of KMT2A and exon 2 of MAML2.Fifty-five percent were men, with a median age of 48 years at surgery (range, 29-69 years). trend trading strategy forex