Etoposide liver toxicity

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August undefined, 2024

WebEtoposide is a podophyllotoxin deriverative with activity against a wide variety of malignancies. It is also used in many clinical conditions in which renal or hepatic function is impaired. To establish a basis for making initial dose adjustments in patients with renal or hepatic dysfunction, the clinical pharmacology (e.g., absorption, distribution, protein … WebJul 11, 2024 · Etoposide is a relatively well-tolerated chemotherapeutic agent. Common adverse effects include alopecia and gastrointestinal toxicity. GI toxicity includes …

Hepatic and Renal dose adjustments of Chemotherapy Drugs

WebPotentiation of preexisting liver disease, especially viral hepatitis. Altered hepatic drug metabolism due to underlying liver disease can result in higher or more persistent drug levels, thereby causing increased systemic toxicity (particularly myelosuppression) or worsening of liver function because of chemotherapy-induced hepatotoxicity. WebSep 12, 2024 · Uncommon but potential severe adverse events include severe neutropenia, bleeding, peripheral neuropathy, pulmonary toxicity, hypersensitivity reactions and embryo-fetal toxicity. Hepatotoxicity Despite being cytotoxic for cancer cells and metabolized actively by the liver, the vinca alkaloids have only rarely been associated with … hafa short sale program

Etoposide (VP 16-213) induced hepatitis. Report of three cases ...

WebDec 6, 2014 · The toxicity difference is likely attributed to other drugs. Response rates were similar between the 2 groups. Our results do not support the empiric dose reduction of etoposide in patients with aggressive lymphomas receiving potentially curative treatment. WebMar 1, 2024 · The present study was designed to investigate the possible protective effect of rosemary extract against Etoposide-induced liver toxicity, injury and KI67 alterations in rats. A total of 40 male ... WebSep 21, 2016 · To investigate the effect of organ function on total and free etoposide pharmacokinetics and hematologic toxicity. PATIENTS AND METHODS Seventy-two patients who received single-agent intravenous (i.v.) etoposide over 5 or 8 days (total dose, 500 mg/m2) were studied. hafas oebb

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WebEtoposide has been shown to reach high concentrations in the liver, thus presenting a potential for accumulation in cases of functional impairment. Patients with impaired … WebJul 25, 2024 · Courses of therapy may be repeated at 3 to 4 week intervals, after adequate recovery from toxicity. Monitoring: Patients should be frequently observed for myelosuppression both during and after therapy. Dose-limiting bone marrow suppression is the most significant toxicity. hafas bene system bin queryWebApr 14, 2024 · Figure 4. atm mutation suppresses the toxic response to etoposide or H 2 O 2 exposure (A) Treatment scheme for exposure to etoposide and H 2 O 2. ( B ) The percent of WT, atm −/− and tp53 −/− embryos that have morphological defects or lethality in response to etoposide or H 2 O 2 . brake fitment centre near me

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Etoposide liver toxicity

Regimen-related toxicity and non-relapse mortality with high …

WebToxicity occurred in patients with normal and abnormal bilirubin and was unrelated to etoposide clearance. Patients with total bilirubin 1.9 to 23 mg/dL, but creatinine clearance greater than 30 mL/min/m2 had etoposide clearance within the range for patients with normal liver function (16.8 to 35 mL/min/m2). WebAug 3, 2024 · Introduction. The liver is not only the most important organ for metabolism and detoxification but also the main site of many biological processes (1-4).Indeed, the liver plays a very important role in metabolism (), bile production (), detoxification (), blood coagulation (), immunity (), and heat generation as well as the regulation of water and …

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WebDose adjustment for baseline liver or renal dysfunction: Each carboplatin dose should be calculated based upon renal function by use of the Calvert formula.* A lower starting dose of etoposide may be needed for patients with renal or liver impairment. [2] ... Suggested dose modifications for toxicity: WebEtoposide DRUG NAME: Etoposide SYNONYM(S): VP-161 COMMON TRADE NAME: VEPESID®, ... syndrome of liver and renal failure, pulmonary deterioration, thrombocytopenia and ascites has been associated with ... monitor toxicity closely high dose cyclosporine with oral etoposide. 14. increase in plasma level in etoposide . …

WebJul 5, 2024 · The echinocandins include anidulafungin, caspofungin, and micafungin and are a relatively new class of antifungal agents that are administered parenterally and are used in therapy or prevention of … http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Etoposide_monograph.pdf

WebDec 20, 2024 · Potential interactions between the liver and chemotherapy fall into two categories: Direct chemotherapy-induced hepatotoxicity. Potentiation of preexisting liver disease, especially viral hepatitis. Altered hepatic drug metabolism due to underlying …

WebTwo cases of toxic hepatitis developing in patients receiving high-dose etoposide (VP-16-213) for refractory germinal neoplasms are described. Each patient received a total cumulative dose of at least 6800 mg/m2. Liver function abnormalities, including hyperbilirubinemia, elevated transaminases, and …

WebMay 5, 2024 · Etoposide: 1.5-3.0 mg/dL or SGOT > 180 units = Administer 50% dosage. Decreased albumin increases unbound drug concentration and increases hematologic toxic eﬀects. Renal. CrCI = 10-50 mL/min = Administer 75% of dosage; CrCI = < 10 mL/min = Administer 50% of dosage; Hemodialysis = Administer 50% of dosage : Fludarabine brakefire incorporatedWebAs a result, dexamethasone (alone and combined with etoposide) has an anti-cancer effect by damaging DNA and inducing oxidative stress. Also, CoQ10 has antioxidant effects against dexamethasone-induced hepatotoxicity by improving mitochondrial function and reducing caspase-3 activity. hafa trading \\u0026 logisticsWebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose limiting. The laboratory observation that forced hydration and diuresis may prevent ... hafas fahrplanheftWebMar 1, 2003 · Liver toxicity was scored by the development of sinusoidal obstruction syndrome (veno-occlusive disease) and by total serum bilirubin levels. The hazards of liver toxicity, nonrelapse mortality, tumor relapse, and survival were calculated using regression analysis that included exposure to cyclophosphamide metabolites (as the area under the ... hafa selling priceWebRarely, etoposide may cause an increase in blood pressure. Cases of myocardial infarction (some fatal) and arrhythmia have been reported. Stomatitis is likely to occur in patients treated with radiation to the head and neck region and has been the dose-limiting toxicity in high-dose etoposide protocols. hafa smoothWebSep 15, 2024 · Liver injury from carboplatin is extremely rare. There is likely to be cross sensitivity to liver toxicities of the various platinum coordination complexes and … hafas rohdatenformatWebNov 5, 2008 · Sehata et al. [ 41, 42] examined the maternal toxicity in detail in pregnant rats exposed to a single oral dose of T-2 toxin (2 mg/kg) on day 13 of gestation. In their experiments, apoptosis was induced in lymphoid, hematopoietic and gastrointestinal tissues and liver as described in the above-mentioned reports in adult mice. hafas routeplanner